# Microsoft Defender for Office 365 vs MimeCast Email Security - 2026 Comparison - Software Advice > Microsoft Defender for Office 365 vs MimeCast Email Security - See how these products stack up against each other with real user reviews, product feature comparisons and screenshots. Find out which one is best for your organization. Source: https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/vs/mimecast-email-security --- [Home](https://www.softwareadvice.com/) / [Email Management Software](https://www.softwareadvice.com/category/3433-email-management/) / Microsoft Defender for Office 365 vs MimeCast Email Security Software Advice offers objective insights based on verified user reviews and independent product and market research. When our advisors match you to a software provider, we may earn a referral fee. Updated June 2, 2026 # Microsoft Defender for Office 365 vs. MimeCast Email Security: 2026 Comparison Skip hours of research. Get your top 5 matches from an expert in 15 minutes, 100% free. Free Expert Guidance Real Human Advice 1M + Businesses Helped Updated June 2, 2026 # Microsoft Defender for Office 365 vs. MimeCast Email Security: 2026 Comparison Skip hours of research. Get your top 5 matches from an expert in 15 minutes, 100% free. Free Expert Guidance Real Human Advice 1M + Businesses Helped Product comparison Compare up to 3 products side-by-side + Add product [](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/) [Microsoft Defender for Office 365](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/) 4.6 [(238)](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/reviews/) Starting Price Not provided by vendor Free trial Free version Pros: Not enough reviews Cons: Not enough reviews Who uses Microsoft Defender for Office 365 Based on 238 reviews - Popular among: Small businesses - Most common industries: IT & Software Development (23%), Professional Services (10%) and Health & Medicine (9%) - Top use case: Email Security (57%) 76% of users recommend this product [](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/) [MimeCast Email Security](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/) 4.3 [(80)](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/reviews/) Starting Price Not provided by vendor Free trial Free version Pros: Not enough reviews Cons: Not enough reviews Who uses MimeCast Email Security Based on 80 reviews - Top use cases: Email Security (19%), Secure Email Gateway (9%) and Email Management (8%) 75% of users recommend this product [](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/) Microsoft Defender for Office 365 4.6 [(238)](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/reviews/) [](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/) MimeCast Email Security 4.3 [(80)](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/reviews/) + Add product Add product ## User satisfaction * * * 4.6 Based on 238 reviews Ease of use 4.5 Value for money 4.5 Customer support 4.3 Functionality 4.5 4.3 Based on 80 reviews Ease of use 4.1 Value for money 4.2 Customer support 4.4 Functionality 4.3 ## User interface * * * ## Key features Features selected based on 318 reviews from Email Management * * * Email Attachment Protection 4.5 Encryption N/A Spam Blocker 4.4 Spam Quarantine 4.4 Whitelisting/Blacklisting 4.6 Email Attachment Protection 4.9 Encryption 4.3 Spam Blocker 4.4 Spam Quarantine 4.8 Whitelisting/Blacklisting N/A ### Wondering if these products fit your needs? Skip the manual research. Talk to a real advisor like Lexi to get a 100% free, personalized shortlist in 15 minutes. LexiAdvisor for 8 years ### Wondering if these products fit your needs? Skip the manual research. Talk to a real advisor like Lexi to get a 100% free, personalized shortlist in 15 minutes. LexiAdvisor for 8 years ## Integrations * * * ## Reviews * * * Swetha C.Technical Program ManangerAutomotive, 5001-10000 employees "It significantly reduces spam, phishing attempts, and malicious email threats while providing administrators with useful visibility into security events." May 31, 2026 NY Natalie Y.Office AssistantAccounting, 11-50 employees "The one thing I don’t like the most is file syncing. While syncing files a very slow performance with file version conflicting." Mar 8, 2026 CJ Chris J.Manager of Security OperationsFood & Beverages, 1001-5000 employees "The reporting abilities helped develop and continue to help improve our metrics program." Mar 24, 2025 Adam F.IT Infrastructure Analyst Oil & Energy, 201-500 employees "As well as retrieving wrongfully deleted mail." Feb 13, 2023 ## Customer support * * * Email/Help Desk FAQs/Forum Knowledge Base Phone Support 24/7 Chat Email/Help Desk FAQs/Forum Knowledge Base Phone Support 24/7 Chat ## Training options * * * In Person Live Online Webinars Documentation Videos In Person Live Online Webinars Documentation Videos ## Popular Comparisons * * * [Hoxhunt vs Microsoft Defender for Office 365](https://www.softwareadvice.com/email-security/hoxhunt-profile/vs/microsoft-defender-for-office-365/)[SpamTitan vs Microsoft Defender for Office 365](https://www.softwareadvice.com/anti-spam/microsoft-defender-for-office-365-profile/vs/spamtitan/)[Hoxhunt vs MimeCast Email Security](https://www.softwareadvice.com/email-security/hoxhunt-profile/vs/mimecast-email-security/)[SpamTitan vs MimeCast Email Security](https://www.softwareadvice.com/marketing/mimecast-email-security-profile/vs/spamtitan/)