# CRIO Software Reviews, Demo & Pricing - 2026 > Review of CRIO Software: system overview, features, price and cost information. Get free demos and compare to similar programs. Source: https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile --- [Home](https://www.softwareadvice.com/) / [Clinical Trial Management Software](https://www.softwareadvice.com/clinical-trial-management/) / CRIO Software Advice offers objective insights based on verified user reviews and independent product and market research. When our advisors match you to a software provider, we may earn a referral fee. Overview [Reviews](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/reviews/)[Alternatives](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/alternatives/) # CRIO 2026: Benefits, Features & Pricing On this page - Overview - User Interface - Popular Alternatives - Pricing and Plans - Features - Integrations - User Reviews - Popular Comparisons ## Overview CRIO 4.5 [(21)](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/reviews/) Pricing Starting at $200.00 per month Top Alternatives ### About CRIO CRIO is a health tech company delivering comprehensive clinical research solutions for pharma, biotech, research sites, and academic research centers to streamline regulatory workflows. As the leading eSource solution for sites worldwide, CRIO’s unique architecture delivers a single point of data capture, eliminating the need for costly and delayed manual re-entry into EDC. ## CRIO User Interface ## Popular CRIO Alternatives Main Product CRIO 4.5 [(21)](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/reviews/) Ratings Breakdown - 4.38Ease of use - 4.40Value for money - 4.70Customer support - 4.38Functionality Pricing Starting at $200.00 per month Alternative Product [ShareCRF](https://www.softwareadvice.com/clinical-trial-management/sharecrf-profile/) 4.8 [(44)](https://www.softwareadvice.com/clinical-trial-management/sharecrf-profile/reviews/) Ratings Breakdown - 4.84Ease of use - 4.60Value for money - 4.79Customer support - 4.64Functionality Pricing Available upon request Alternative Product [Castor EDC](https://www.softwareadvice.com/data-collection/castor-edc-profile/) 4.7 [(204)](https://www.softwareadvice.com/data-collection/castor-edc-profile/reviews/) Ratings Breakdown - 4.70Ease of use - 4.59Value for money - 4.74Customer support - 4.49Functionality Pricing Available upon request Alternative Product [Researchmanager – Clinical Research Suite](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/) 4.2 [(114)](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/reviews/) Ratings Breakdown - 3.97Ease of use - 4.03Value for money - 3.99Customer support - 3.98Functionality Pricing Available upon request Alternative Product [EDGE](https://www.softwareadvice.com/product/220291-EDGE/) 4.9 [(35)](https://www.softwareadvice.com/product/220291-EDGE/reviews/) Ratings Breakdown - 4.91Ease of use - 4.85Value for money - 4.94Customer support - 4.49Functionality Pricing Starting at £1000.00 per year Alternative Product [Health Cloud](https://www.softwareadvice.com/remote-patient-monitoring/salesforce-health-cloud-profile/) 4.5 [(40)](https://www.softwareadvice.com/remote-patient-monitoring/salesforce-health-cloud-profile/#reviews) Ratings Breakdown - 4.28Ease of use - 3.97Value for money - 4.20Customer support - 4.40Functionality Pricing Starting at $350.00 per month ## CRIO Pricing and Plans Starting price: $200.00 per month Free Trial Free Version Licensing $200.00 flat rate, per month No plan information available ## CRIO Features - Popular features found in Clinical Trial Management 21 CFR Part 11 Compliance Data Capture and Transfer Data Import/Export Document Management Electronic Data Capture Financial Management Inventory Management Patient Management Patient Monitoring Patient Recruiting Scheduling Workflow Management - More features of CRIO Access Controls/Permissions Activity Dashboard Activity Tracking Ad hoc Reporting Alerts/Notifications API Approval Process Control Audit Trail Calendar Management Clinical Study Management Configurable Workflow CRF Tracking Customizable Branding Customizable Fields Customizable Forms Customizable Reports Customizable Templates Data Extraction Data Storage Management Data Visualization Digital Signature Document Storage Electronic Signature EMR/EHR Enrollments/Onboarding Forms Management HIPAA Compliant Monitoring Multi-Language Progress Tracking Real-Time Data Real-Time Monitoring Real-Time Reporting Reminders Remote Data Capture Reporting/Analytics Reporting & Statistics Role-Based Permissions Secure Data Storage Third-Party Integrations Trial Design User Management ## CRIO Integrations Microsoft Outlook Integration rated undefined from -1 review ## CRIO User Reviews Overall Rating 4.5 Ratings Breakdown 5 76% 4 14% 3 0% 2 5% 1 5% Secondary Ratings Ease of Use 4.4 Value for money 4.4 Customer support 4.7 Functionality 4.4 LA W. Verified reviewer Used daily for less than 12 months Review source Reviewed November 2017 Super efficient, friendly support, proactive company focused on site needs & industry demands. 5 The time spent in clinic and entering data has been cut to less than half. We are continuing to learn about all of the functions of this software and have not been dissappointed in anything yet. The capabilities are endless and the cost is affordable. Big pharma should jump at the chance at having real time data available. This has been a game changer at our site. We only have 2 coordinators so we were limited in our study load. We have doubled our study load within 6 months of starting with CRIO. You will not find a single system that offers all that CRIO does and for the price too! Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: This is the creme de la creme of clinical research software. There are so many modules and training that it will take some time to get used to but you will never be sorry. If you seriously commit to learning and using this system you will save so much time from capturing data real time to decreasing errors and deviations. I absolutely love the reponse time from the CRIO team and the "live chat" feature has saved our site from having any major meltdowns due to the learning curve. Our site is almost completely paperless thanks to this amazing software. Comments from CRA's : "this is the wave of the future" "your site is so far ahead in the game, why aren't all sites using this?" " what is it called again?" The game changer for our site was the financial tracker module. We are a small site so using Fresh Books, an EMR, a CTMS, and entering data in respective EDC's took an incredible amount of time... time wasted entering data trifold and trying to track what we are owed vs paid & costs to our vendors , study staff etc. Major bonus points for this system that our site was not looking for was the recruiting module. This system is truly a one stop shop. Better is efficiency in what we do, how we do it, without compromising the integrity of the data. Data entry errors across multiple systems compromises data, creates queries and wastes time. CRIO does interface with other data systems making data entry at the site occur one time. Imagine that! Read More JR Jodi R. Verified reviewer Research 2-10 employees Used daily for less than 2 years Review source Reviewed June 2021 Seamless record keeping at the tip of your fingers 5 Ratings Breakdown 4 Ease of use 4 Value for money 5 Customer support 4 Functionality Pros: CRIO is very user friendly, comprehensive, and easy to implement. We were able to train staff and begin utilizing CRIO 100% within 3 weeks of purchase. Cumbersome tasks, such as charting are now streamlined, allowing us to become more productive and better concentrate on our patient population. Cons: The eReg function is cumbersome and not quite as user friendly as the rest of the CRIO software. It would be great if it had the same look and feel as the majority of the suite, and if it were not billed separately. Reasons for switching to CRIO Clinical Conductor was not user friendly AT ALL. We were 6 months in and still unable to implement it! Read More DT Derek T. Verified reviewer Hospital & Health Care 11-50 employees Used daily for more than 2 years Review source Reviewed August 2021 Bugs Bugs and more Bugs 2 The software has not lived up to the expectation, and their growing price point has made it a thorn in the side of their long-time customers. Ratings Breakdown 2 Ease of use 1 Value for money 1 Customer support 2 Functionality Pros: This software has a clean user interface and the price point was lower than most competitors. Cons: CRIO was new to the market when we signed up. They promised routine and frequent updates to improve the software. What we got was prioritizing poorly planned and implemented useless features over fixing the bug and issues in their core product. The e-regulatory is almost completely useless. Reasons for switching to CRIO Price and e-Regulatory Features Vendor Response Hi Derek, Thank you for your response. My name it Tony Sciucco and I'm the Director of Customer Success here at CRIO. We'd love an opportunity to connect with you directly regarding your feedback and have a more in depth conversation. Could you reach out to me directly at tony.sciucco@clinicalresearch.io to set up a time to speak? Thanks and looking forward to connecting. Tony Replied August 2021 Read More JH Jill H. Verified reviewer Research 2-10 employees Used daily for more than 2 years Review source Reviewed October 2020 If you can believe it, It just keeps GETTING BETTER 5 We have found their platform to be very user-friendly and it helps with every aspect of managing a clinical study at our site. From patient recruitment to invoicing for a final payment they cover everything for us. Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: I originally signed on to Clinical Research IO three years ago for an eSource solution. Since then I have switched to their CTMS solution, eRegulatory solution as well. We also started using their Recruitment module, texting/calling solution, and patient stipends. EVERY MODULE is fantastic. What I believe is their strongest suit, however, is their customer service and dedication to continued quality and enhancements. They keep adding to their services and really are a "total solution" company for sites. Cons: The final piece I'd like to see from them is eConsent.... but I'm told that's coming so I'm very much looking forward to this solution. Reasons for choosing CRIO Clinical Research IO seemed to flow better and was more intuitive to us than RealTime. Reasons for switching to CRIO I wanted one vendor (and one sign-on) that handles everything. That way our whole system "talks" to each other and each job duty is housed in the same system- making our overall workflow so much more efficient. Read More DW Donte W. Verified reviewer Pharmaceuticals 11-50 employees Used daily for more than 2 years Review source Reviewed June 2021 Clinical Researcher Life with CRIO 5 Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: The patient monitoring, financial management and using one systems to streamline our process has main our operation run more efficiently. Cons: Making the change from paper source and using the CRIO platform entirely was the hardest adjustment. It was the same with making the change from paper charts to EMR. Reasons for choosing CRIO We decided on CRIO based on the systems ability to integrate with all aspects or our organization. The platform functions in an inclusive capacity that integrated all clinical research areas (i.e. regulatory, clinical coordination, quality assurance, CRO monitoring, contract management). Read More CB Christine B. Verified reviewer Hospital & Health Care 201-500 employees Used daily for less than 2 years Review source Reviewed March 2025 CRIO - a great e-source 5 Overall, CRIO is easy to use for source documentation. The customer support is top notch. They assign one person to our account and she responds quickly and efficiently to any needs that arise and also makes time to meet with our team as needed. Ratings Breakdown 5 Ease of use 4 Value for money 5 Customer support 5 Functionality Pros: CRIO has an excellent interface for electronic source with plenty of room to add additional paper documents as needed and electronically sign them. Cons: The recruitment module (or perhaps our usage of it) is a bit clunky with lots of required steps. Every patient has 2 profiles, which are linked, but it's odd. Read More NS Naina S. Verified reviewer Hospital & Health Care 201-500 employees Used daily for less than 2 years Review source Reviewed September 2024 Great tool 4 Ratings Breakdown 4 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: Esource and econsent options are really great Cons: Connectivity issues can cause disruption during visits Read More JG James G. Verified reviewer Medical Practice 11-50 employees Used daily for more than 2 years Review source Reviewed June 2021 CRIO - finally and all in one clinical research management software. 5 Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: For an investigator, the most impactful feature of CRIO is the ability to monitor a subjects process, review and sign off on ancillary studies from anywhere a computer, tablet or cell phone can connect to the CRIO server. The days of piles of paper charts with sticky notes to lead the investigator to new data to review is over. A simple mouse click puts all investigators 'to do' items at his/her fingertips. Cons: A module for informed consent electronic signature for subjects and research staff would be desirable. Read More VR Verified Reviewer Pharmaceuticals 11-50 employees Used daily for less than 12 months Review source Reviewed September 2020 A Fundamentally Broken product that will frustrate you to no end! DO NOT BUY THIS 1 Absolutely the worst product I have ever used. Even typing in a diagnosis becomes an issue. Everything is so much more complicated than it needs to be. This is a waste of money and this company should not even be in business. Ratings Breakdown 1 Ease of use 1 Value for money 5 Customer support 1 Functionality Pros: Nothing - this product is not worth anything because it will never truly work. You will never stop experiencing problems. Cons: This product is absolutely FULL of broken functionalities and errors. There isn't a day go by where a basic function stops working and I need to contact their customer support. They never fix these issues permanently and leave most of the implementation work for you to do. They nickel and dime and ultimately their software designers choose the most idiotic choices that leave the software unnecessarily complicated to use. DO NOT BUY THIS SOFTWARE. If you do, you will experience what I have and you will remember this review! Read More Ryan L. Verified reviewer Used daily for less than 12 months Review source Reviewed November 2017 Excellent clinical research software with great value for the cost. 4 Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 4 Functionality Pros: \-UI is very clean and easily navigated. -Source creation that is simple for anyone with some advanced features. -Frequent updates and improvements. -Payment model that makes sense for research sites. -External logins allow monitors to leave comments directly on the eSource form! Cons: \-Simplistic source creation doesn't lend itself to specific needs. As an ophthalmology practice, best-corrected visual acuity is impossible to adequately and efficiently capture on this platform. That said, I haven't seen a system that can do much better. -They took an interesting approach of starting with a complicated form and simplifying it as you answer questions rather than vice versa. I don't dislike it but would prefer the alternative for the purposes of clinical research. Read More Showing 1 - 10 of 21 Reviews [See All Reviews](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/reviews/) ## CRIO Popular Comparisons [RealTime-CTMS vs CRIO](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/vs/realtime-ctms/) [Compare All Alternatives](https://www.softwareadvice.com/clinical-trial-management/clinical-research-io-profile/alternatives/) ## See what companies are saying about Software Advice