# OpenClinica Software Reviews, Demo & Pricing - 2026 > Review of OpenClinica Software: system overview, features, price and cost information. Get free demos and compare to similar programs. Source: https://www.softwareadvice.com/clinical-trial-management/openclinica-profile --- [Home](https://www.softwareadvice.com/) / [Web-Based EMR Software](https://www.softwareadvice.com/medical/web-based-emr-software-comparison/) / OpenClinica Software Advice offers objective insights based on verified user reviews and independent product and market research. When our advisors match you to a software provider, we may earn a referral fee. Overview [Reviews](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/)[Alternatives](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/alternatives/) # OpenClinica 2026: Benefits, Features & Pricing Wondering if OpenClinica is right for your practice? Our Web-Based EMR Software selection experts can help you in 15 minutes or less. On this page - Overview - User Interface - Popular Alternatives - Pricing and Plans - Features - User Reviews - Popular Comparisons ## Overview OpenClinica 4.6 [(37)](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) Pricing Starting at $1,000.00 per month ### About OpenClinica OpenClinica is a clinical data management and electronic data capture solution designed to help medical institutions capture electronic data and streamline clinical trials using electronic case report forms (eCRFs) and a drag-and-drop interface. For patient-reported outcomes, patients can respond to forms and surveys on any device of their choosing. Physicians can collect patients' information using responsive mobile forms and share operational reports with team members. Organizations can create multiple treatment groups, label drug kits with randomization codes, and sort trial lists based on age, sex, test site or electronic case report forms (eCRF). Using OpenClinica, professionals can view operational data in the form of bar charts, graphs or key performance indicators and maintain organizational compliance with Good Clinical Practice (GCP), 21 CFR Part 11, and other industry standards. Additionally, clinicians can use the dashboard to import/export files, review site activities, and track the progress of ongoing trials. For total study control, OpenClinica integrates and partners with Bio-Optronics to provide advanced functionality over research operations. OpenClinic... a also provides an open-source version, OpenClinica Community Edition, on GitHub to provide users greater control over the technology. Wondering if OpenClinica is right for your practice? Our Web-Based EMR Software selection experts can help you in 15 minutes or less. ## OpenClinica User Interface ## Popular OpenClinica Alternatives Main Product OpenClinica 4.6 [(37)](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) Ratings Breakdown - 4.35Ease of use - 4.44Value for money - 4.67Customer support - 4.31Functionality Pricing Starting at $1000.00 per month Get Price Alternative Product [Researchmanager – Clinical Research Suite](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/) 4.2 [(115)](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/reviews/) Ratings Breakdown - 3.98Ease of use - 4.03Value for money - 4.0Customer support - 3.99Functionality Pricing Available upon request Get Price Alternative Product [ClinCapture](https://www.softwareadvice.com/clinical-trial-management/clincapture-profile/) 4.9 [(21)](https://www.softwareadvice.com/clinical-trial-management/clincapture-profile/#reviews) Ratings Breakdown - 4.90Ease of use - 4.81Value for money - 4.94Customer support - 4.74Functionality Pricing Starting at $2000.00 per month Get Price Alternative Product [Medrio](https://www.softwareadvice.com/clinical-trial-management/medrio-profile/) 4.6 [(51)](https://www.softwareadvice.com/clinical-trial-management/medrio-profile/reviews/) Ratings Breakdown - 4.69Ease of use - 4.61Value for money - 4.73Customer support - 4.21Functionality Pricing Available upon request Get Price Alternative Product [Encapsia](https://www.softwareadvice.com/clinical-trial-management/encapsia-profile/) 5.0 [(2)](https://www.softwareadvice.com/clinical-trial-management/encapsia-profile/#reviews) Ratings Breakdown - 5.0Ease of use - 5.0Value for money - 5.0Customer support - 4.50Functionality Pricing Available upon request Get Price Alternative Product [Castor EDC](https://www.softwareadvice.com/data-collection/castor-edc-profile/) 4.7 [(204)](https://www.softwareadvice.com/data-collection/castor-edc-profile/reviews/) Ratings Breakdown - 4.70Ease of use - 4.59Value for money - 4.74Customer support - 4.49Functionality Pricing Available upon request Get Price ## OpenClinica Pricing and Plans Starting price: $1,000.00 per month Free Trial Free Version Basic $1,000.00 per month No plan information available Confused about pricing? We've got you covered. Get a personalized pricing breakdown tailored to your specific needs—no guesswork, no generic estimates. ## OpenClinica Features - Features of OpenClinica 21 CFR Part 11 Compliance Activity Dashboard Alerts/Notifications API Audit Trail Clinical Study Management CRF Tracking Customizable Fields Customizable Forms Data Capture and Transfer Data Import/Export Data Verification Data Visualization Distributed Capture Double Data Entry Drag & Drop Electronic Data Capture Electronic Signature EMR/EHR Forms Management HIPAA Compliant Inventory Management Monitoring Patient Management Patient Monitoring Randomization Reminders Remote Data Capture Reporting/Analytics Reporting & Statistics Scheduling Secure Data Storage User Management Web Forms Workflow Management ## OpenClinica User Reviews Overall Rating 4.6 Ratings Breakdown 5 76% 4 19% 3 3% 2 0% 1 3% Secondary Ratings Ease of Use 4.4 Value for money 4.4 Customer support 4.7 Functionality 4.3 Vanessa G. Verified reviewer Research 11-50 employees Used weekly for more than 2 years Review source Reviewed February 2024 OpenClinica for Investigator led Clinical Trials in the UK 5 Ratings Breakdown 5 Ease of use 5 Customer support 5 Functionality Pros: Easy to create and update forms for data collection Cons: Automatic scheduling is a bit limited, however this is planned to be updated soon Reasons for choosing OpenClinica Overall value, together with compliance and support Read More KK Krister K. Verified reviewer Information Technology and Services 2-10 employees Used daily for more than 2 years Review source Reviewed February 2024 Why I cannot live without OpenClinica 5 I have worked with OpenClinica for more than 15 years and loved how it has developed Ratings Breakdown 5 Ease of use 4 Value for money 5 Customer support 5 Functionality Pros: The ease of set up a new study and the management functions Cons: I cannot think of anything, have worked with clinical studies my entire professional life and used any tool on the market and OpenClinica has resolved all the issues. Reasons for choosing OpenClinica We had already used the free version of OpenClinica when we decided Reasons for switching to OpenClinica Cost and ease of set up including all the tools that has developed since. We started with the open source version Read More BF Bethany F. Verified reviewer Research 201-500 employees Used daily for more than 2 years Review source Reviewed November 2022 An honest review 3 I loved building the study. The options for designing forms are diverse, though some of them require learning additional skillsets to be able to implement, which they don't explain to you in the training. The design tool is lacking but once you get the hang of designing with the spreadsheets there are a lot of possibilities. Many queries cannot be sustained easily by their build in data validation system and you will need to use an external querying system to appropriately manage all the data. This would have been good to know from the beginning. They charge you for training hours but require you to use them within a certain timeframe or they expire. It's a use it or lose it thing. I don't remember that being a thing until the last year and I really don't like it at all. If I pay for the training hours that I'm forced to by in certain hour blocks of time then I should get to use them whenever I need them, not in a window of time that OC thinks is reasonable. They are paid for. The customer service people are always friendly and helpful. Some training sessions go really well, especially when you are with someone hire up on the support team, but there have been many sessions where the trainer is referring to a manual to instruct me on my question and I lose a lot of my "training hours" waiting for them to figure it out and then pass on the information. I'd prefer to just have the manual and figure it out myself. Ratings Breakdown 1 Ease of use 2 Value for money 3 Customer support 2 Functionality Pros: I love the diversity in the form design. There are a lot of great features and possibilities that can make a very sophisticated form/study. Cons: The built in edit checks/constraints are very limited in what they can do. The stuff they have is great, but the ability to do cross-form logic checks gets very messy, very fast and for some of the most simple data. You have to use a separate system to access the database for reports and full audit details called Insight and you have to pay extra to use that with your study. It's the only way to find and send reports to sites/safety teams that do not have access to Insight. The automated survey invitation tool is a mess. The system easily breaks and invitations do not get sent out as expected and the means to test this for accuracy is very difficult so you feel like you are setting up a tool blindly that is most expected to fail. The sites get very frustrated and do not trust the software to help them keep their visits on track and completed as expected. We have also run into problems where participants can access surveys too early. There has been a lot of clean up work we've had to do and a lot of hours spent trying to find all the errors since the querying system is limited in it's design to pretty basic edit checks. Cross form date checks are not at all easy and very much needed to quickly catch the system errors that happen. The randomization tool is pretty sophisticated but it also costs extra and whenever you need to do updates to the tool it's a much more difficult process then simply publishing it to test. This also adds layers of difficulty to the testing. Vendor Response Hi Bethany, We appreciate your feedback (both positive and negative). While we feel like it should have overall warranted a few more stars, we'd like to offer some assistance and clarifications: Even though most customers who use the survey tool find it to work exceptionally well, knowing how best to configure it for a particular use case is important. Our support and customer success teams are always happy to discuss your particular use case and provide guidance on best practices. We are making a number of enhancements to the way calendaring-style logic and notifications are configured, which I suspect may help with your particular study design. We will reach out to you directly to make sure you understand how to optimally apply the capabilities that exist today, as well as the new ones coming soon. OpenClinica offers extensive documentation online to help customers successfully build and run studies. As you commented, our support, professional services, and success teams are always ready to lend a hand! Training can be consumed within 6 months, which for most customers is quite reasonable. We are usually happy to provide an extension to this timeline if requested, however. Thank you for you continuing to trust us with your studies for the past 14 years. We are all looking forward to an ongoing, successful partnership with valued customers such as yourself. Replied November 2022 Read More RN Ranjan N. Verified reviewer Medical Devices 11-50 employees Used daily for less than 12 months Review source Reviewed November 2020 Moving in the right direction 5 Overall switching to OpenClinica has brought numerous benefits to our data collection methods. The learning curve for some employees has been steep, however, a few months in I can claim that it was worth the effort. I look forward to whatever new features/updates OpenClinica team has planned in the future. Ratings Breakdown 4 Ease of use 5 Customer support 5 Functionality Pros: OpenClinica offers a wide array of features for electronic data collection. Specifically the customizability of the forms and events when designing a survey has benefitted us immensely. Additionally, the OpenClinica team members work hard to both understand what their users need and proactively update the software with new features. Cons: Sometimes there are minor delays on some customer support requests. Reasons for choosing OpenClinica We were impressed with features that OpenClinica had and that they were planning to roll out. Our quality folks were also very happy with steps taken by OpenClinica to maintain a high standard of quality. Reasons for switching to OpenClinica Old software with limited features and an outdated UI. No GDPR compliance. Newer version was priced extremely high. Vendor Response Thank you for your review and candor Ranjan. We remain steadfast in our mission and passion to reduce complexity while maintaining powerful capabilities. Replied November 2020 Read More AB Angelica B. Verified reviewer Pharmaceuticals 5001-10000 employees Used daily for free trial Review source Reviewed June 2023 Enhancing Clinical Trials with OpenClinica: A Comprehensive Review 5 I had the chance to collaborate with OpenClinica while I was interning at the university's pharmaceutical product development and research division. The program was essential in organizing the data from research projects and clinical trials. I saw first-hand how OpenClinica's flexible form builder enabled us to precisely develop and collect study-specific data items. The software's user-friendly interface streamlined and expedited the data entering process, decreasing errors and cutting down on data entry time. Our research on the efficacy and safety of medications was supported by OpenClinica's reporting and analytics capabilities, which gave us insights into patient demographics, treatment outcomes, and adverse events. Overall, OpenClinica was a great help in organizing and processing the data we needed for our research activities. Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: For clinical research investigations, OpenClinica has a number of benefits. The program, in the first place, offers a versatile and scalable data management platform that enables researchers to create and collect study-specific data items. The data entry procedure is streamlined, lowering errors and increasing efficiency thanks to its user-friendly interface and intuitive form builder. Researchers can get insightful knowledge from gathered data using OpenClinica's powerful reporting and analytics features, promoting the use of evidence in decision-making. In order to guarantee data integrity and safety, the program also enables regulatory compliance, including data security and audit trails. Overall, OpenClinica equips scientists with a full suite of tools for trustworthy and effective data management in clinical trials and studies. Cons: Even though OpenClinica has many advantages, there are a few things to keep in mind. First off, the initial setup and configuration process can be challenging and complicated, necessitating qualified technical knowledge. For non-technical users, the software's advanced functionality could have a longer learning curve, demanding thorough training and continuous assistance. Users have occasionally reported experiencing performance issues with the system, especially when working with huge datasets or intricate study designs. Additionally, for smaller research institutions with tighter budgets, the cost structure of the program can be a barrier. Despite these factors, OpenClinica is a smart choice for clinical research studies due to its flexibility, extensive data management capabilities, and compliance features. Read More Adam P. Verified reviewer Research 2-10 employees Used daily for more than 2 years Review source Reviewed February 2024 OC4 for Oncology Clinical Trials 5 Ratings Breakdown 5 Ease of use 4 Value for money 5 Customer support 4 Functionality Pros: The support provided by the Openclinica team cannot be beat. If I may list two things, the OC system is incredibly user friendly. Cons: We needed a centralised system to collect quesitonnaire responses from participants, record that data, enter clinical results, and upload copies of paper work related to each participant visit. This system provides all of the above. Read More Yama G. Verified reviewer Research 10000+ employees Used daily for more than 2 years Review source Reviewed December 2018 I use OC 3 for over five years and found it a good electronic data capture system 4 OC is a great application for clinical trial research projects. It is easy to use and easy to build CRFs. The user support team is very helpful and there is a big community of people who could be helpful. The new version of the application OC4 seems to be very promising and the team has done a great job with interdicting new functionalists. Ratings Breakdown 4 Ease of use 5 Value for money 5 Customer support 4 Functionality Pros: OC there is an excellent application for clinical trial projects. - It is easy to build a CRF, and one does not need a technical background to develop a CRF. - It supports multi-site studies. - It supports multi-event studies - It supports multi CRFs per event studies - Support multi-section (tabs) and multi group CRF - Supports repeating events - Support grid layout questions which is helpful (e.g. if you wont record participant's medication history) - User-friendly interface - compatible with Firefox, internet explore and Chrome - Good user support - Easy to install Cons: \- OC 3 interface is not responsive ( OC4 is responsive) - No offline data entry capability - Programmer skills are needed to implement complex validations during CRF design Read More Andrew M. Verified reviewer Research 51-200 employees Used weekly for more than 2 years Review source Reviewed October 2020 Powerful form designs that compete with products ten times the price. 5 Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 4 Functionality Pros: Having worked with OpenClinica and other EDC systems for several years, OpenClinica puts all the others to shame when it comes to customer service; their team bends over backward to help train, explain and fix. The software is continually improving based on user feedback. The forms are very powerful and have almost every feature you might need: conditional display, modern responsive interface, touch friendly, lots of question types, conditional requirement, programmable notes to users. The new version (OC4) is considerably easier to develop than OC3: no coding required, if you can write Excel functions then you can use even the moved advanced features. SDTM compatible examples of the most common OpenClinica eCRFs are readily available. It's much cheaper than alternatives and has some features that I have only seen on the most high end products: question libraries, one-click deployment, advanced user inputs (eg drawings, VAS), localisation features, customisable ID generation etc. Cons: The older version (OC3) requires coding experience to make the nost of it. I recommend avoiding OC3 and using OC4 instead. Reasons for switching to OpenClinica OpenClinica was much easier to use maintain and change that bespoke software. Vendor Response Thank you for your review Andrew. It's great to hear from a seasoned data manager. We appreciate your acknowledgment of our team's diligent work toward greater usability and capability. Replied October 2020 Read More VR Verified Reviewer Hospital & Health Care Used daily for more than 2 years Review source Reviewed April 2018 Personalization options are impressive 4 OpenClinica makes it easy to us to keep track of a huge number of patients in the same place and query it for studies. Ratings Breakdown 4 Ease of use 5 Functionality Pros: I continue to be impressed by how many ways we can personalize OpenClinica to our clinic setting. We were able to select the different categories we want completed for each patient, as well as unique drop-down options for everyone. Cons: The version of OpenClinica we use does not look very modern. It doesn't affect the functionality of the software, but could be nicer to look at. Vendor Response Thank you for the candid and encouraging review. Let us help you transition to the latest release, OC4. You'll find the ultra-modern (and ultra-powerful) UX you deserve! https://openclinica.com/contact-openclinica/ Replied May 2018 Read More Dominique F. Verified reviewer Hospital & Health Care 51-200 employees Used daily for less than 2 years Review source Reviewed November 2022 OpenClinica review 5 Ratings Breakdown 5 Ease of use 5 Value for money 5 Customer support 5 Functionality Pros: smart data collector tool through survey on patients in hospital care operations help to earn time easy to use outcome report in form of tests and graphic very faster than other measures Cons: request for customer support is some time slowthe money value of the tool is still expensive for small hospitals Read More Showing 1 - 10 of 37 Reviews [See All Reviews](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) ## OpenClinica Popular Comparisons [Castor EDC vs OpenClinica](https://www.softwareadvice.com/data-collection/castor-edc-profile/vs/openclinica/)[Viedoc vs OpenClinica](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/vs/viedoc/) [Compare All Alternatives](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/alternatives/) ## Other Top Recommended Web-Based EMR Software [athenaOne](https://www.softwareadvice.com/medical/athenacollector-athenaclinicals-profile/) **3.8** (911) Recently recommended **209** times [AdvancedMD EHR](https://www.softwareadvice.com/product/1018-AdvancedEHR/) **3.6** (464) Recently recommended **202** times [RXNT](https://www.softwareadvice.com/medical/rxnt-emr-profile/) **4.3** (498) Recently recommended **175** times [CharmHealth](https://www.softwareadvice.com/medical/charmehr-profile/) **4.2** (151) Recently recommended **144** times Stuck Between Options? 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