# Best 15 OpenClinica Alternatives in 2026 - Software Advice > Find the top OpenClinica Software alternatives in 2026. Our list is fueled by product features and real user reviews and ratings. Compare these alternatives to make sure you are picking the best Web-Based EMR Software for your business. Source: https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/alternatives --- 1 million+ businesses helped. Get advice Get Free Advice [Home](https://www.softwareadvice.com/) / [Web-Based EMR Software](https://www.softwareadvice.com/medical/web-based-emr-software-comparison/) / [OpenClinica](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/) / OpenClinica Alternatives Software Advice offers objective insights based on verified user reviews and independent product and market research. When our advisors match you to a software provider, we may earn a referral fee. [Overview](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/)[Reviews](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) Alternatives # Best 15 OpenClinica Alternatives OpenClinica 4.6 [(37)](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) Starting Price: $1,000.00 per month Free trial Free version Find your perfect match Speak directly with a specialist to match alternatives to your budget and needs. On this page - Popular Alternatives - Alternatives - Popular Comparisons ## Preview of Top OpenClinica Alternatives Main Product OpenClinica 4.6 [(37)](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/reviews/) Ratings Breakdown - 4.35Ease of use - 4.44Value for money - 4.67Customer support - 4.31Functionality Pricing Starting at $1000.00 per month Get Price Top Alternative Researchmanager – Clinical Research Suite 4.2 [(115)](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/reviews/) Ratings Breakdown - 3.98Ease of use - 4.03Value for money - 4.0Customer support - 3.99Functionality Pricing Available upon request Get Price Top Alternative ClinCapture 4.9 [(21)](https://www.softwareadvice.com/clinical-trial-management/clincapture-profile/#reviews) Ratings Breakdown - 4.90Ease of use - 4.81Value for money - 4.94Customer support - 4.74Functionality Pricing Starting at $2000.00 per month Get Price Top Alternative Encapsia 5.0 [(2)](https://www.softwareadvice.com/clinical-trial-management/encapsia-profile/#reviews) Ratings Breakdown - 5.0Ease of use - 5.0Value for money - 5.0Customer support - 4.50Functionality Pricing Available upon request Get Price Top Alternative Medrio 4.6 [(51)](https://www.softwareadvice.com/clinical-trial-management/medrio-profile/reviews/) Ratings Breakdown - 4.69Ease of use - 4.61Value for money - 4.73Customer support - 4.21Functionality Pricing Available upon request Get Price Top Alternative Castor EDC 4.7 [(204)](https://www.softwareadvice.com/data-collection/castor-edc-profile/reviews/) Ratings Breakdown - 4.70Ease of use - 4.59Value for money - 4.74Customer support - 4.49Functionality Pricing Available upon request Get Price ## OpenClinica Alternatives [### Researchmanager – Clinical Research Suite](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/) 4.2 [(115)](https://www.softwareadvice.com/clinical-trial-management/research-manager-profile/reviews/) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 71% Unique Features for Researchmanager – Clinical Research Suite - Access Controls/Permissions - Barcode/Ticket Scanning - Compliance Management See All 29% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 100% Unique Integrations for Researchmanager – Clinical Research Suite - AFAS Software - Clue - Fitbit See All 0% Shared Integrations with OpenClinica - No shared integrations See Researchmanager – Clinical Research Suite Screenshots [### ClinCapture](https://www.softwareadvice.com/clinical-trial-management/clincapture-profile/) 4.9 [(21)](https://www.softwareadvice.com/clinical-trial-management/clincapture-profile/#reviews) Starting Price: $2000.00 per month Free trial Free version Starting Price: $2000.00 per month Free trial Free version ### Features Comparison 82% Unique Features for ClinCapture - Access Controls/Permissions - API - Approval Process Control See All 18% Shared Features with OpenClinica - Audit Trail - CRF Tracking - Data Capture and Transfer ### Integrations Comparison 100% Unique Integrations for ClinCapture - CTMS Master - EHR Solutions - Epic See All 0% Shared Integrations with OpenClinica - No shared integrations See ClinCapture Screenshots [### Encapsia](https://www.softwareadvice.com/clinical-trial-management/encapsia-profile/) 5.0 [(2)](https://www.softwareadvice.com/clinical-trial-management/encapsia-profile/#reviews) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 0% Unique Features for Encapsia - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 100% Unique Integrations for Encapsia - Positive User 0% Shared Integrations with OpenClinica - No shared integrations See Encapsia Screenshots [### Medrio](https://www.softwareadvice.com/clinical-trial-management/medrio-profile/) 4.6 [(51)](https://www.softwareadvice.com/clinical-trial-management/medrio-profile/reviews/) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 57% Unique Features for Medrio - Data Import/Export - Data Storage Management - Data Verification See All 43% Shared Features with OpenClinica - Clinical Study Management - Data Capture and Transfer - HIPAA Compliant ### Integrations Comparison 0% Unique Integrations for Medrio - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See Medrio Screenshots [### Castor EDC](https://www.softwareadvice.com/data-collection/castor-edc-profile/) 4.7 [(204)](https://www.softwareadvice.com/data-collection/castor-edc-profile/reviews/) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 71% Unique Features for Castor EDC - Access Controls/Permissions - API - Customizable Forms See All 29% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 100% Unique Integrations for Castor EDC - eCRF 0% Shared Integrations with OpenClinica - No shared integrations See Castor EDC Screenshots [### Flex Databases platform](https://www.softwareadvice.com/product/456034-Flex-Databases-platform/) 4.5 [(13)](https://www.softwareadvice.com/product/456034-Flex-Databases-platform/#reviews) Starting Price: $1300.00 per month Free trial Free version Starting Price: $1300.00 per month Free trial Free version ### Features Comparison 68% Unique Features for Flex Databases platform - Access Controls/Permissions - Calendar Management - Compliance Management See All 32% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 100% Unique Integrations for Flex Databases platform - Castor EDC - Medidata CTMS - Medrio See All 0% Shared Integrations with OpenClinica - No shared integrations See Flex Databases platform Screenshots [### Dacima Clinical Suite](https://www.softwareadvice.com/electronic-data-capture/dacima-clinical-suite-profile/) 5.0 [(5)](https://www.softwareadvice.com/electronic-data-capture/dacima-clinical-suite-profile/#reviews) Starting Price: CA$100.00 per month Free trial Free version Starting Price: CA$100.00 per month Free trial Free version ### Features Comparison 0% Unique Features for Dacima Clinical Suite - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 0% Unique Integrations for Dacima Clinical Suite - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See Dacima Clinical Suite Screenshots [### RealTime-CTMS](https://www.softwareadvice.com/clinical-trial-management/realtime-ctms-profile/) 4.9 [(66)](https://www.softwareadvice.com/clinical-trial-management/realtime-ctms-profile/reviews/) Starting Price: $500.00 per month Free trial Free version Starting Price: $500.00 per month Free trial Free version ### Features Comparison 71% Unique Features for RealTime-CTMS - Compliance Management - Data Import/Export - Data Visualization See All 29% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 100% Unique Integrations for RealTime-CTMS - Mailchimp - Microsoft Outlook - Twilio 0% Shared Integrations with OpenClinica - No shared integrations See RealTime-CTMS Screenshots [### Viedoc](https://www.softwareadvice.com/clinical-trial-management/viedoc-profile/) 4.4 [(95)](https://www.softwareadvice.com/clinical-trial-management/viedoc-profile/reviews/) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 68% Unique Features for Viedoc - Activity Dashboard - API - Data Import/Export See All 32% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 0% Unique Integrations for Viedoc - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See Viedoc Screenshots [### TrialKit](https://www.softwareadvice.com/clinical-trial-management/trialkit-profile/) 4.5 [(35)](https://www.softwareadvice.com/clinical-trial-management/trialkit-profile/reviews/) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 60% Unique Features for TrialKit - Compliance Management - Data Import/Export - Data Storage Management See All 40% Shared Features with OpenClinica - 21 CFR Part 11 Compliance - Audit Trail - Clinical Study Management See All ### Integrations Comparison 0% Unique Integrations for TrialKit - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See TrialKit Screenshots [### Xolomon](https://www.softwareadvice.com/medical/xolomon-profile/) 4.0 [(20)](https://www.softwareadvice.com/medical/xolomon-profile/#reviews) Starting Price: €5000.00 one time Free trial Free version Starting Price: €5000.00 one time Free trial Free version ### Features Comparison 0% Unique Features for Xolomon - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 0% Unique Integrations for Xolomon - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See Xolomon Screenshots [### SyMetric](https://www.softwareadvice.com/electronic-data-capture/symetric-c6-profile/) No reviews yet Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 0% Unique Features for SyMetric - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 100% Unique Integrations for SyMetric - Medidata CTMS - Medrio - SAP HANA Cloud See All 0% Shared Integrations with OpenClinica - No shared integrations See SyMetric Screenshots [### EvidentIQ eCOA](https://www.softwareadvice.com/clinical-trial-management/evidentiq-profile/) No reviews yet Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 0% Unique Features for EvidentIQ eCOA - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 100% Unique Integrations for EvidentIQ eCOA - Castor EDC - Cloudbyz CTMS - Marvin EDC See All 0% Shared Integrations with OpenClinica - No shared integrations See EvidentIQ eCOA Screenshots [### MainEDC](https://www.softwareadvice.com/clinical-trial-management/mainedc-profile/) 4.8 [(5)](https://www.softwareadvice.com/clinical-trial-management/mainedc-profile/#reviews) Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 0% Unique Features for MainEDC - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 100% Unique Integrations for MainEDC - Flex Databases platform - Medidata CTMS - Salesforce Platform 0% Shared Integrations with OpenClinica - No shared integrations See MainEDC Screenshots [### oomnia](https://www.softwareadvice.com/product/496447-Oomnia-EDCCTMS-System/) No reviews yet Pricing: Available upon request Free trial Free version Pricing: Available upon request Free trial Free version ### Features Comparison 0% Unique Features for oomnia - No unique features 0% Shared Features with OpenClinica - No shared features ### Integrations Comparison 0% Unique Integrations for oomnia - No unique integrations 0% Shared Integrations with OpenClinica - No shared integrations See oomnia Screenshots ## Popular OpenClinica Comparisons [Castor EDC vs OpenClinica](https://www.softwareadvice.com/data-collection/castor-edc-profile/vs/openclinica/)[Viedoc vs OpenClinica](https://www.softwareadvice.com/clinical-trial-management/openclinica-profile/vs/viedoc/) Still Not Sure? Our experts can help you compare OpenClinica with other top options, so you can find the best fit for your needs. Best 15 OpenClinica Alternatives in 2026 - Software Advice