CRIO 2026: Benefits, Features & Pricing

This is the creme de la creme of clinical research software. There are so many modules and training that it will take some time to get used to but you will never be sorry. If you seriously commit to learning and using this system you will save so much time from capturing data real time to decreasing errors and deviations. I absolutely love the reponse time from the CRIO team and the "live chat" feature has saved our site from having any major meltdowns due to the learning curve. Our site is almost completely paperless thanks to this amazing software. Comments from CRA's : "this is the wave of the future" "your site is so far ahead in the game, why aren't all sites using this?" " what is it called again?" The game changer for our site was the financial tracker module. We are a small site so using Fresh Books, an EMR, a CTMS, and entering data in respective EDC's took an incredible amount of time... time wasted entering data trifold and trying to track what we are owed vs paid & costs to our vendors , study staff etc. Major bonus points for this system that our site was not looking for was the recruiting module. This system is truly a one stop shop. Better is efficiency in what we do, how we do it, without compromising the integrity of the data. Data entry errors across multiple systems compromises data, creates queries and wastes time. CRIO does interface with other data systems making data entry at the site occur one time. Imagine that!

CRIO is very user friendly, comprehensive, and easy to implement. We were able to train staff and begin utilizing CRIO 100% within 3 weeks of purchase. Cumbersome tasks, such as charting are now streamlined, allowing us to become more productive and better concentrate on our patient population.

The eReg function is cumbersome and not quite as user friendly as the rest of the CRIO software. It would be great if it had the same look and feel as the majority of the suite, and if it were not billed separately.

This software has a clean user interface and the price point was lower than most competitors.

CRIO was new to the market when we signed up. They promised routine and frequent updates to improve the software. What we got was prioritizing poorly planned and implemented useless features over fixing the bug and issues in their core product. The e-regulatory is almost completely useless.

I originally signed on to Clinical Research IO three years ago for an eSource solution. Since then I have switched to their CTMS solution, eRegulatory solution as well. We also started using their Recruitment module, texting/calling solution, and patient stipends. EVERY MODULE is fantastic. What I believe is their strongest suit, however, is their customer service and dedication to continued quality and enhancements. They keep adding to their services and really are a "total solution" company for sites.

The final piece I'd like to see from them is eConsent.... but I'm told that's coming so I'm very much looking forward to this solution.

The patient monitoring, financial management and using one systems to streamline our process has main our operation run more efficiently.

Making the change from paper source and using the CRIO platform entirely was the hardest adjustment. It was the same with making the change from paper charts to EMR.

CRIO has an excellent interface for electronic source with plenty of room to add additional paper documents as needed and electronically sign them.

The recruitment module (or perhaps our usage of it) is a bit clunky with lots of required steps. Every patient has 2 profiles, which are linked, but it's odd.

Esource and econsent options are really great

Connectivity issues can cause disruption during visits

For an investigator, the most impactful feature of CRIO is the ability to monitor a subjects process, review and sign off on ancillary studies from anywhere a computer, tablet or cell phone can connect to the CRIO server. The days of piles of paper charts with sticky notes to lead the investigator to new data to review is over. A simple mouse click puts all investigators 'to do' items at his/her fingertips.

A module for informed consent electronic signature for subjects and research staff would be desirable.

Nothing - this product is not worth anything because it will never truly work. You will never stop experiencing problems.

This product is absolutely FULL of broken functionalities and errors. There isn't a day go by where a basic function stops working and I need to contact their customer support. They never fix these issues permanently and leave most of the implementation work for you to do. They nickel and dime and ultimately their software designers choose the most idiotic choices that leave the software unnecessarily complicated to use. DO NOT BUY THIS SOFTWARE. If you do, you will experience what I have and you will remember this review!

-UI is very clean and easily navigated. -Source creation that is simple for anyone with some advanced features. -Frequent updates and improvements. -Payment model that makes sense for research sites. -External logins allow monitors to leave comments directly on the eSource form!

-Simplistic source creation doesn't lend itself to specific needs. As an ophthalmology practice, best-corrected visual acuity is impossible to adequately and efficiently capture on this platform. That said, I haven't seen a system that can do much better. -They took an interesting approach of starting with a complicated form and simplifying it as you answer questions rather than vice versa. I don't dislike it but would prefer the alternative for the purposes of clinical research.