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CRIO vs RealTime-CTMS

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CRIO vs RealTime-CTMS: 2026 Comparison

Updated December 12, 2025
Starting Price
$200.00

per month

$500.00

per month

Free Trial
Free Version
Screenshots
and Demo
Product Screenshot
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Product Screenshot
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Top Rated
  Features
21 CFR Part 11 Compliance
5.0
HIPAA Compliant
5.0
Document Management
4.33
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Financial Management
4.86
Patient Monitoring
4.86
Patient Management
4.86
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Integrations
Microsoft Outlook
Microsoft Outlook
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Mailchimp
Mailchimp
Twilio
Twilio
Microsoft Outlook
Microsoft Outlook
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Pros / Cons
  • We had been looking for a system that is very easy to use, had multiple features that cater to clinical research (scheduling, payment tracking, eSource, archiving etc) for a very long time but none of the existing systems could provide a complete package.......until I came across CRIO.
  • The software has not lived up to the expectation, and their growing price point has made it a thorn in the side of their long-time customers.
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  • It would be such a time saver and minimize the risk of errors during data entry.
  • It is not very easy to post a check that is paid with many line items and payment amounts that need to be adjusted to match the sponsor payment. When emailing invoice to sponsor, there is no mechanism to ensure email was received such as a reach receipt by Sponsor.
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Ease-of-Use
4.4/ 5
Highest performing feature
in the comparison
4.7/ 5
Value for Money
4.4/ 5
Highest performing feature
in the comparison
4.8/ 5
Customer Support
4.7/ 5
Highest performing feature
in the comparison
4.9/ 5
Functionality
4.4/ 5
Highest performing feature
in the comparison
4.7/ 5
Support Options
Email/Help Desk
FAQs/Forum
Knowledge Base
Phone Support
24/7 (Live Rep)
Chat
Email/Help Desk
FAQs/Forum
Knowledge Base
Phone Support
24/7 (Live Rep)
Chat
Training Options
In Person
Live Online
Webinars
Documentation
Videos
In Person
Live Online
Webinars
Documentation
Videos
FrontRunners
N/A
N/A
Advisor
  Recommendations
N/A
N/A
Ideal Customer Size
Small
Medium
Large
Small
Medium
Large
Deployment Options
Cloud, SaaS, Web-Based
Desktop - Mac
Desktop - Windows
Desktop - Linux
Desktop - Chromebook
On-Premise - Windows
On-Premise - Linux
Mobile - Android
Mobile - iPhone
Mobile - iPad
Cloud, SaaS, Web-Based
Desktop - Mac
Desktop - Windows
Desktop - Linux
Desktop - Chromebook
On-Premise - Windows
On-Premise - Linux
Mobile - Android
Mobile - iPhone
Mobile - iPad