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athenahealth, recently ranked #1 by 2023 Best in KLAS for athenaClinials Ambulatory EMR for 11-75 physicians and athenaIDX practice management, provides cloud-based services for electronic health records (EHR), revenue cycle manag...Read more about athenaOne

3.8 (785 reviews)

344 recommendations


RXNT’s cloud-based, ONC-certified medical software—Billing, Practice Management, EHR, and more—improves clinical outcomes & revenue cycle management. Simple, transparent pricing includes free setup and training, free data transfer...Read more about RXNT

4.3 (406 reviews)

320 recommendations


DrChrono’s iPad and iPhone compatible EHR and medical billing platform allows medical practices and healthcare providers to manage patient intake, patient care, clinical charting, billing and revenue cycle management. It includes ...Read more about DrChrono

4.0 (474 reviews)

290 recommendations

ChartLogic EHR

ChartLogic offers an ambulatory EHR suite that includes electronic medical record, practice management, revenue cycle management, e-prescribing and patient portal. The solution caters to primary care, surgical care and other compl...Read more about ChartLogic EHR

3.9 (62 reviews)

88 recommendations

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Elation Health

Elation Health is the most trusted technology platform for high-value primary care. Since 2010, the company has delivered clinical-first solutions — built on a collaborative EHR platform — that help practices start, grow, communic...Read more about Elation Health

4.4 (51 reviews)

54 recommendations

NextGen Office

NextGen Office is an award-winning, cloud-based, clinical and billing solution designed for smaller, independent practices (≤ 10 providers). This all-in-one, full-service solution includes specialty-specific EHR content, an easy-t...Read more about NextGen Office

4.0 (1253 reviews)

29 recommendations


Nexus is an ONC 2015 Edition certified cloud-based ambulatory EHR and PM platform. It is designed for small to midsize practices and a variety of specialties including orthopedics, neurology, podiatry, cardiology, general surgery,...Read more about Nexus

4.6 (9 reviews)

26 recommendations


DocVilla is a HIPAA-compliant Cloud-based software for medical practices. DocVilla offers integrated EHR (Electronic Health Records), EMR (Electronic Medical Records), Telemedicine, Electronic Prescriptions (eRx), EPCS (Electronic...Read more about DocVilla

5.0 (1 reviews)

23 recommendations


CharmHealth is a MU certified, cloud-based EHR, Practice Management and Medical Billing solution that helps healthcare organizations ranging from large multi-specialty groups to small independent medical offices function efficient...Read more about CharmHealth

4.3 (126 reviews)

15 recommendations


NewCrop is a comprehensive prescribing software solution that can be used with a wide variety of electronic medical systems. NewCrop is designed to integrate with any EMR or EHR system. NewCrop includes industry-leading functional...Read more about NewCrop

5.0 (1 reviews)

14 recommendations


Harmony e/Notes is a hybrid integrated solution that offers functionalities for electronic medical records, practice management, billing and revenue cycle management. Specialities that the solution caters to include cardiology, ge...Read more about HARMONY Medical

4.5 (24 reviews)

8 recommendations

TriMed Complete

TriMed offers a complete software suite which includes Electronic Health Records, Practice Management, Patient Portal, Mobile, Check-in Module, and Telemedicine. Our products are fully integrated, so all modules seamlessly work to...Read more about TriMed Complete

5.0 (46 reviews)

2 recommendations


Looking to harness the full power of the Tebra platform? Our practice success platform includes a certified electronic health record solution built to empower today’s providers with robust clinical charting, streamlined documentat...Read more about Tebra

Practice Fusion

Founded in 2005, Practice Fusion offers a cloud-based EHR that includes a suite of integrated features like charting, e-prescribing, patient scheduling, lab and imaging integration and more. Additionally, practices can qualify for...Read more about Practice Fusion


Pabau's all-in-one software is built to handle everything that clinics (both large and small) need to run smoothly. Forget spreadsheets, integrations, paper notes and scanning — do it all from one easy to use tool. - Save 12+ ...Read more about Pabau

Qualifacts Insync

Enhance patient care with InSync's fully integrated, easy-to-use, cloud-based healthcare IT solutions configured specifically to your practice and workflows. EHR, practice management, medical billing, telemedicine, e-prescribing a...Read more about Qualifacts Insync

Cerner Ambulatory

Cerner's PowerChart Ambulatory EHR is a hybrid EHR solution that caters to clinicians in hospitals and ambulatory facilities. PowerChart is designed to help with multi-entity electronic medical record creation. This solution can b...Read more about Cerner Ambulatory

Veradigm Practice Management

Veradigm Practice Management is a cloud-based solution designed to simplify and optimize the daily operations of physician practices. The platform offers a range of features, including scheduling and appointment management, billin...Read more about Veradigm Practice Management


MDToolbox-Rx is a cloud-based solution designed to help medical organizations of all sizes send electronic prescriptions to various pharmacies. A Surescripts and EPCS-certified solution, it enables users to access patient history ...Read more about MDToolbox-Rx

Provet Cloud

Provet is a cloud-based practice management solution for veterinary clinics and hospitals of all sizes. Key features include online bookings, client communication, patient records, imaging and laboratory device connectivity and re...Read more about Provet Cloud

Buyers Guide

Last Updated: March 16, 2023

The prescription pad has been redesigned for the digital age, and it’s changing the way patients get the medication they need. Doctors are now turning to electronic prescribing (e-prescribing) software instead of paper-based notes to handle their prescription orders. In fact, according to Maryville University, just over 70% of physicians currently use e-prescribing software.

Software providers are taking notice of the demand for electronic prescription software. As a result, there are hundreds of solutions available for practices to purchase. In this guide, we’ll break down what you need to know before selecting the right e-prescribing software for your organization.

Here’s what we’ll discuss:

What Is E-Prescribing Software?

Common Functionality of E-Prescribing Software

Deployment Strategies

Market Trends to Understand

What Is E-Prescribing Software?

E-prescribing software is a tool that allows you to electronically generate and transmit a prescription order directly from a healthcare provider to a patient’s pharmacy of choice. In other words, doctors can create and send a patient’s prescription using their computer or mobile device, rather than using manual methods (e.g., phone calls and faxes) to contact pharmacies.

Electronic prescriptions are transmitted through private, secure and closed networks maintained by e-prescribing software vendors. These networks are able to connect with the vast majority of pharmacies across the country.

The government has supported e-prescriptions by passing laws incentivizing their adoption, such as the Medicare Improvements for Patients and Providers Act (MIPPA) of 2003 and the Health Information Technology for Economic and Clinical Health (HITECH) Act of 2009. This is likely due to the software’s many benefits, which include:

  • Enhanced patient safety: Doctors and users can identify drug interactions and allergies before finalizing a prescription because of built-in alert systems integrated into the software.

  • Faster access to patient information: Prescribers can access a patient’s insurance formularies, eligibility information, and a list of current or past medications.

  • Improved accuracy: Doctors have access to patient histories at the click of a button which gives a more holistic picture of their health and reduces the chance of prescribing errors.

  • Increased patient convenience: Patients only need to take one trip to the pharmacist when filling or refilling a prescription because doctors can send medication orders digitally to the pharmacy.

  • Guaranteed legibility: Pharmacists won’t have trouble reading a prescriber’s handwriting with digitally sent prescriptions, making dosage and drug information more accurate.

Patient medication calendar (Source)

For all these reasons, electronic prescribing has been lauded as a more accurate, efficient and safe alternative to handwritten prescriptions.

Common Functionality of E-Prescribing Software

Software providers offer a variety of functional breadth and depth in their e-prescribing solutions. Here are some of the most common capabilities:

Medication selection

Prescribers can typically choose from more than one option when searching for a medication to include in the prescription order, including generic alternatives to brand-name drugs.

Prescription creation and submission

Users can generate new prescriptions to be sent directly to a pharmacy from their desktop computer or mobile device. These orders can be processed individually or several at a time. Order management tools are typically included to ensure pharmacies have received prescriptions.

Adverse interaction checks

Most systems offer alerts and warnings for a variety of potential adverse reactions from a particular prescription, such as drug interactions, allergies, dosage amounts and duplicates.

Refill authorizations

Pharmacies can send refill requests to prescribers directly through the software's network. Providers can then approve or deny these requests electronically.

Medication history views

Most solutions allow users to access a patient’s medication history by importing it from a pharmacy’s database, or through the medication claims history provided by insurance payers/pharmacy benefit managers.

Doctor notes and allergy information when prescribing new medication (Source)

Deployment Strategies

E-prescribing vendors offer their products through one of two deployment models: standalone applications, or electronic health records (EHR) suites that include electronic prescription capabilities along with several other applications (e.g., patient scheduling and billing).

After all, it's easier to implement an e-prescribing system that’s integrated with a practice management solution out of the box. Integrating a third-party e-prescribing product with existing EHR software is generally more difficult.

On the other hand, standalone or “best-of-breed” programs have the benefit of being less expensive than EHR suites, in most cases. Since the user is only paying for one application as opposed to three or more, the fee for service isn’t usually as high.

Your budget and the size of your practice will be the determining factors when it comes to deciding between a best-of-breed system and an integrated EHR suite. Large and midsize practices with greater resources and multiple prescribers will likely be better served by comprehensive EHR suites than by standalone e-prescribing systems.

Market Trends to Understand

Government initiatives and incentive programs: One of the key drivers of adopting e-prescribing are the incentive programs launched by the government to improve healthcare quality, reduce healthcare costs and minimize prescription errors (Source: NCBI). The National Council for Prescription Drugs Program, a pharmacy standards development organization, has developed specialized standards for e-prescribing. The implementation of government initiatives, such as the American Recovery and Reinvestment Act (2009), and Drug Enforcement Administration’s rule allowing electronic prescription of controlled substances (EPCS) have assisted in increasing the use of e-prescribing.

In Europe, eHealth projects, such as the Schleswig-Holstein Health initiative and European Patient Smart Open Services (epSOS), have helped increase the adoption of e-prescribing systems (Source: Persistence Market Research).

Investments in healthcare IT: Rising investments in healthcare IT have increased the adoption of EHR software and other technology. Gartner states that “digital healthcare is propelling spending in enhancing core automation systems like various health information systems and other associated technologies”. Improved infrastructure and expansion of healthcare IT have helped in the growth of e-prescribing technology. The growing adoption of integrated EHR models has also aided the e-prescribing market.

Advancements in e-prescribing technology: Persistence Market Research also says that advanced e-prescribing features, such as data security checks, patient history, preparing complete medication lists and information of formulary, are also key drivers of this market. These advancements have helped expand the scope and quality of patient care.

Improved efficiency and reduced expenses: According to Statista, 80% of all prescriptions are written digitally. This has helped the industry improve efficiency, reduce medication errors and enjoy cost-saving benefits.

High costs, security and connectivity issues hinder adoption of e-prescribing systems: The high costs of e-prescribing systems and risks associated with privacy and patient security restrain the growth of the e-prescribing market. Other factors include unavailability of high-speed broadband services and integrated networks, especially in developing countries. The absence of competent IT professionals and laws to protect patient privacy discourage pharmacies and healthcare professionals from switching to e-prescribing systems.


The shift to electronic prescribing systems can save funds and manual efforts in the healthcare industry. Additional features offered by these systems help to improve patient care efficiency. Improvements in IT infrastructure and investments in digital healthcare will help improve adoption of e-prescribing systems. Companies that become early adopters will reap the benefits sooner than those who don’t.