Best Prescription Writing Software of 2026
Updated January 27, 2025 at 9:58 AM
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RXNT’s cloud-based, ONC-certified medical software—Billing, Practice Management, EHR, and more—improves clinical outcomes & reve...Read more about RXNT
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athenaOne® is the most comprehensive all-in-one solution for healthcare practices to remain independent. It includes electronic ...Read more about athenaOne
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NextGen® Office is an all-in-one, cloud-based support system designed to help independent practices improve clinical outcomes, i...Read more about NextGen Office
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PatientNow is an EMR practice management software designed for aesthetic and wellness providers. It supports various specialties...Read more about PatientNow
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ReLi Med Solutions' suite gives small to midsize ambulatory care practices a completely integrated EHR and Practice Management s...Read more about ReLiMed

ModMed is a cloud-based electronic health record (EHR) and practice management system designed for specialty medical practices. ...Read more about ModMed
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PrognoCIS EHR and PrognoCIS Telemedicine have earned a reputation for fast, flexible individual provider workflow. The software ...Read more about PrognoCIS
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Nextech is redefining what’s possible in specialty healthcare. As an award-winning technology partner for specialty practices an...Read more about Nextech EHR & PM
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RevolutionEHR is a cloud-based electronic health record (EHR) solution built specifically for optometry practices. RevolutionEHR...Read more about RevolutionEHR
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NextGen Healthcare provides ambulatory practices of all sizes award-winning solutions along with dedicated support and professio...Read more about NextGen Enterprise
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AllegianceMD is a cloud-based medical software system that is designed to serve the needs of small and midsize practices, as wel...Read more about AllegianceMD

TotalMD is an extremely affordable, extremely intuitive Practice Management solution that offers small and growing practices the...Read more about TotalMD
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ChiroTouch is the leading all-in-one chiropractic EHR and practice management software, trusted by over 12,500 practices across ...Read more about ChiroTouch
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Advanced Data Systems provides healthcare software designed to streamline clinical and administrative workflows for various medi...Read more about Advanced Data Systems
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LiquidEHR is a cloud-based electronic health record (EHR) solution suitable for small and midsize optometry practices. It offers...Read more about Liquid EHR
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IMS (Intelligent Medical Software) by Meditab Software is an Electronic Health Records (EHR) and Practice Management solution th...Read more about Intelligent Medical Software

myEvolv is an ONC-certified electronic health record (EHR) with comprehensive clinical, financial and operational features. It w...Read more about myEvolv

MedEZ is an electronic health record (EHR) and billing suite suitable for most medical facilities, particularly behavioral healt...Read more about MedEZ

With over two decades of unparalleled expertise in revolutionizing healthcare, OmniMD stands as a catalyst in reshaping traditio...Read more about OmniMD
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Experity is a software offering a comprehensive suite of solutions designed to streamline operations and improve patient care. ...Read more about Experity

Sightview is a practice management solution built for ophthalmologists and optometrists. Key features include fully customizable...Read more about Sightview
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Buyers Guide
This detailed guide will help you find and buy the right prescription writing software for you and your business.
Last Updated on January 27, 2025Everyone knows the old jokes about doctors having bad handwriting. They're funny because they're so often true. At the same time, they're not at all funny because bad handwriting actually leads to serious mistakes.

Illegible handwritten medication prescriptions are the subject of many funny-not-funny jokes
According to a 2006 study, covered by Time magazine, "Doctors' sloppy handwriting kills more than 7,000 people [...] and injures more than 1.5 million Americans [...]. Many such errors result from unclear abbreviations and dosage indications and illegible writing on some of the 3.2 billion prescriptions written in the U.S. every year."
As the number of prescriptions written annually keeps rising—up to nearly 4.5 billion in the US in 2016—it's clear that a solution to the problem is needed. Thankfully, a simple solution already exists. Dedicated prescription writing software is one tool in the vast family of medical software and is the subject of this Buyer's Guide. In it we cover:
What Is Prescription Writing Software?
Common Features of Prescription Writing Software
What Is Prescription Writing Software?
Prescription writing software is a group of dedicated applications and software platform add-ons that help doctors create, print, record and transmit prescriptions. Doctors and practices seeking broader functionality should begin their search by reading our medical software Buyer's Guide.

Pharmacy selection screen in NextGen Healthcare's integrated medical software platform
As the National Academies of Science, Engineering and Medicine writes, "Medication administration is founded on what are termed the 'five rights'—the right drug, in the right dose, by the right route, at the right time, to the right patient."
That's a lot to get right! Prescription writing software helps get it all right every time, by helping health care providers avoid mistakes caused by oversights, transcription errors or just messy handwriting.
Common Features of Prescription Writing Software
While features vary considerably depending on whether the prescription writing software is used on its own or as part of a larger integrated suite of medical software, some common features to know about include the following:
Patient information | Helps fill out prescriptions with patient information (name, address, date of birth etc.) obtained through integration with patient electronic health records (EHRs) or other digital records. |
Drug search | Lets prescribers search and select from a database of medication options, including those for over-the-counter (OTC) medications, drug nicknames and generic alternatives. |
Medication history views | With EHR integration, medication history views provide information on a patient's current and past prescription history. |
Adverse interaction checks | Helps prescribers stay on top of any potential drug interactions by checking for drug allergies and other contraindications. |
E-prescribe | Electronically transmit new prescriptions directly to a pharmacy or receive refill requests from a pharmacy. |
One-click prescribing and refills | More automated implementation of e-prescribe and one-click functions streamline the prescribing and refill processes. |
EHR integrations | General back-end functionality that supports many more advanced prescription writing software features, such as integration with medication histories. |
Certifications | Prescription writing software may be certified by a number of third-parties, including the Electronic Healthcare Network Accreditation Commission (EHNAC) |
Certifications for Prescription Writing Software
There are many laws and regulations that govern how a health care provider can store, use and transmit information related to a patient's health. Importantly, these laws apply to the providers of health care, but not to the software they use. This means that if a practice uses software that runs afoul of these laws, then it's the practice that's on the hook and not the software vendor.
Thankfully, there are a number of groups and commissions that provide accreditations. One example, the Electronic Healthcare Network Accreditation Commission (EHNAC) describes itself as a "nonprofit accrediting body designed to improve transactional quality, operational efficiency and data security in health care."

EHNAC accreditations available to prescribers, prescription writing software platforms and pharmacies
Regarding prescriptions specifically, EHNAC has accreditations for software, pharmacies and practices. Prescription writing software buyers can improve their chances at full compliance by looking for vendors that have these or similar accreditations.
Market Trends to Understand
Move toward mobile devices
It's no secret that the world is rapidly moving toward digitalization. From online learning to online appointment scheduling and everything in between, new uses for digital communications are unfolding almost daily. In the health care sphere, the move to electronic health records (EHRs) is one of the most obvious manifestations of this larger trend.
In a previous survey, Software Advice learned that health care providers use a variety of devices to access and input information to EHRs:
Device Used to Access EHRs

Interestingly, though a majority reported using desktop computers, those using mobile devices (tablets, smartphones) actually reported a higher level of satisfaction:
Satisfaction With EHR, by Device Type Used

While many offices have implemented desktop/laptop computers into their workflows, the evidence suggests they'd be more satisfied if they made the switch to mobile devices. Buyers of prescription writing software should take this into consideration and look for software with good mobile device compatibility.
Digitalization opens door to better health outcomes
Much of the discussion about the benefits of prescription writing software focuses on efficiency and error prevention. While clearly important, there are other benefits worth noting. Namely, many of the medical world's up-and-coming advancements will be most readily available to practices that have embraced digital technologies in their workflows.
Look at genomics-based drug selection as one example. In the report "Predicts 2017: Healthcare Providers Take a Step Toward Digital Business" (available to Gartner clients), Richard Gibson notes that:
An increasing number of drugs can be predicted to be ineffective or toxic, based on a person's genomics.
Avoiding ineffective drugs leads to use of other, better medications and faster patient recovery.
But how will prescribers find the time to weigh all these additional factors? They won't need to. Instead, prescription writing software will work quietly behind the scenes and offer medication suggestions that the evidence has shown to work most effectively with particular markers in that patient's genome.
That's just one example, but it's a good one. It shows how transitioning now to a digital practice will open up opportunities down the road.


